 Docking Ligand: |
| IBI provides services for docking putative drug compounds (ligands) in the active site of drug proteins. Most protein contains pockets, cavities surface depressions and other geometrical regions where small molecules compounds can easily bind. Our researchers generate structures for protein and ligands orient themselves in protein active sites. This can help in finding different substrates for enzymes, optimizing reactions and designing inhibitors for different drug target proteins.
|
|
|
|
|
In lead optimization our researchers systematically modify the structure of the lead compound, docking each specific configuration of a drug compound in a protein's active site, and then testing how well each configuration binds to the site. In a common lead optimization method known as bioisosteric replacement, specific functional groups in a ligand are substituted for other groups to improve the binding characteristics of the ligand. Our researchers can examine the various bioisosteric groups and their docking configurations, choosing only those that bind well in active site. |
|
|
|
|
Drug design is a process used in biopharmaceutical industry to discover and develop new drug compounds. We use a variety of computational methods to identify novel compounds, design compounds for selectivity, efficacy and safety. these methods fall into several natural categories such as structure-based drug design, ligand-based drug design, de novo design and homology modeling depending on how much information is available about drug targets and potential drug compounds. Drug targets are typically key molecules involved in a specific metabolic or cell signaling pathway that is known, or believed, to be related to a particular disease state. Drug targets are most often proteins and enzymes in these pathways. We can design drug compounds to inhibit, restore or otherwise modify the structure and behavior of disease related proteins and enzymes. |
|
|
|
|
Comparative model building consists of the extrapolation of the structure for a new (target) sequence from the known 3D-structure of related family members (templates). Our researchers have great experience in modeling different protein structures, the different active sites present and predicting their functions. Robust protocols have been developed to predict protein/protein interactions and protein/ligand interactions. This can help in predicting the affinity of drugs and other substrates towards their proteins. We can decide over different purification techniques by predicting the interactions of the proteins or compounds that are to be purified. |
|
|
|
|
Immune cells recognize epitopes (antigenic determinants) rather than entire antigens. Epitopes are the regions of an antigen that are bound by antigen-specific membrane receptors on lymphocytes or to secreted antibodies. T-cell epitopes, which are usually linear peptides derived from protein antigens and presented by MHC molecules. We have a robust protocol to predict these epitopes which can be further used for vaccine development. |
|
|
|
|
Our efficient researchers can perform all the genome and proteome analysis like Sequence Comparison - Sequence Alignment - Sequence Manipulation - Phylogeny - Promoter Prediction & Transcription Regulation - Exon & ORF Prediction - Alternate Splicing - RNA Secondary Structure - siRNA Design - Protein Sequence Analysis - Protein Translations - Domain, Motifs and Signatures - Transmembrane Presiction - Subcellular Localization - Protein Modifications - Protein Splicing - Molecular Modeling - Transcriptional Profiling - Genome Analysis & Annotation - Sequence Analysis Servers - Gene Annotation - Primer Design. |
|
|
|
|
Services include Knowledge management, Data Mining, Database Management, Relational Database Conversion & Project Management. We develop and deploy customized databases for R & D. Our team of skilled and experienced researches provides data-mining services and annotation of chemical, biological, pharmacological, and toxicity information from patents, journals or targets. Information is curated in custom designed formats to meet specific client requirements. |
|
|
|
|
Collecting and exploring relevant data address many issues in the health, medical and biological sciences. The development and application of techniques to better understand and interpret such data is the fundamental concern of our group in Biostatistics. IBI offers services in the field of statistics and biostatistics using industry best software's such as SAS and SPSS. |
|
|
|
|
Our experienced team of researchers can design customized algorithms or software tools suiting user's requirement. Our team is skilled and well equipped with the different languages like BioPerl, C, C++, Java, .NET applications, MySQL, Oracle etc. We have an experience of designing web compatible as well as stand alone software's for bioinformatics. |
|
|
|
|
These services include Molecular Modeling Studies, Lead Generation,
Virtual Screening, ADME and toxicological Property Prediction and biodegradability. |
|
|
|
|
| Researchers need to communicate their research to the rest of world and the best way to do is by putting their research on the Internet. We provide customized solutions in which we design and deploy technical websites and database. We are using different web languages like DHTML, XML, ASP, PHP etc. We use different platforms like CGI, DBI etc. |
|
|
|
|
Our experienced Biomedical writers are well versed with the writing skills and they understand that to submit the research papers in the best journals they have to communicate the research in the simplest and accurately written English. They have a flair for writing and would write our research in the manner in which it is required by the best international research journals. |
|
|
|
|
| IBI is the industry leaders in Bioinformatics trainings. Trainings programs could be custom designed according to the client's requirements. The duration could range from 1 week to 6 months. Our programs are attended by researchers, students, teachers and trainers. for more information on our training programs please log on to www.ibieducare.org |
|
| For any further queries
services@ibibiosolutions.com |
